Abstract: We want to estimate the prevalence of latent tuberculosis infection (LTBI) in the United States using the tuberculin skin test (TST) and with an interferon-gamma release assay (IGRA), based on 2011-2012 National Health and Nutrition Examination Survey. LTBI was measured by both the TST and QuantiFERON®-TB Gold In-Tube test (QFT-GIT). Statistical issues and related modeling will be discussed.